Zhongguo Zhong Xi Yi Jie He Za Zhi. 1999 May;19(5):296-8.

[Experimental study on apoptosis induced by ursolic acid isolated from asparagus in HL-60 cells]
[Article in Chinese]

* Huang J,
* Sun Y,
* Lu S.

Cancer Hospital and Institute, Peking Union Medical University, Chinese Academy of Medical Sciences, Beijing (100021).

OBJECTIVE: To study the inhibitory effect of ursolic acid isolated from Asparagus on the proliferation of HL-60 cells. METHODS: Effects of ursolic acid on the growth and apoptosis were evaluated by MTT assay, DNA gel electrophoresis and morphology observation respectively. RESULTS: The IC50 value of ursolic acid for HL-60 cells was found to be 8.26 mumol/L and 10-50 mumol/L of ursolic acid could induce apoptosis of HL-60 cells expressed to ursolic acid for 1 day. CONCLUSION: Ursolic acid can markedly inhibit HL-60 cells as well as induction of cells apoptosis.

PMID: 11783246 [PubMed - indexed for MEDLINE]